Association of the germline BRCA2 missense variation Glu2663Lys with high sensitivity to trabectedin-based treatment in soft tissue sarcoma

We report an interesting clinical case of a patient carrying a specific BRCA2 germline variant affected by bone and hepatic metastases from a high grade uterine stromal sarcoma who obtained a complete metabolic response after only 3 cycles of trabectedin treatment (1.5 mg/m(2) given intravenously ov...

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Dettagli Bibliografici
Pubblicato in:Cancer Biol Ther
Autori principali: Miolo, Gianmaria, Viel, Alessandra, Canzonieri, Vincenzo, Baresic, Tania, Buonadonna, Angela, Santeufemia, Davide Adriano, Lara, Della Puppa, Corona, Giuseppe
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2016
Soggetti:
Bedside to Bench Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079400/
https://ncbi.nlm.nih.gov/pubmed/27561088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2016.1219812
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