Creatinine Clearance Is Associated with Toxicity from Molecularly Targeted Agents in Phase I Trials

OBJECTIVES: This study aimed to evaluate any correlations between baseline creatinine clearance and the development of grade 3/4 toxicities during treatment within oncology phase I trials of molecularly targeted agents where entry criteria mandate a serum creatinine of ≤1.5 × the upper limit of norm...

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Detalhes bibliográficos
Publicado no:Oncology
Main Authors: Basu, B., Vitfell-Pedersen, J., Moreno Garcia, V., Puglisi, M., Tjokrowidjaja, A., Shah, K., Malvankar, S., Anghan, B., de Bono, J.S., Kaye, S.B., Molife, L.R., Banerji, U.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2012
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079100/
https://ncbi.nlm.nih.gov/pubmed/22889980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000341152
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