Protein Carbonylation of an Amino Acid Residue of the Na/K‐ATPase α1 Subunit Determines Na/K‐ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells

BACKGROUND: We have demonstrated that cardiotonic steroids, such as ouabain, signaling through the Na/K‐ATPase, regulate sodium reabsorption in the renal proximal tubule. By direct carbonylation modification of the Pro222 residue in the actuator (A) domain of pig Na/K‐ATPase α1 subunit, reactive oxy...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Yan, Yanling, Shapiro, Anna P., Mopidevi, Brahma R., Chaudhry, Muhammad A., Maxwell, Kyle, Haller, Steven T., Drummond, Christopher A., Kennedy, David J., Tian, Jiang, Malhotra, Deepak, Xie, Zi‐jian, Shapiro, Joseph I., Liu, Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079028/
https://ncbi.nlm.nih.gov/pubmed/27613772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.003675
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