Discovery and Clinical Evaluation of MK‐8150, A Novel Nitric Oxide Donor With a Unique Mechanism of Nitric Oxide Release

BACKGROUND: Nitric oxide donors are widely used to treat cardiovascular disease, but their major limitation is the development of tolerance, a multifactorial process to which the in vivo release of nitric oxide is thought to contribute. Here we describe the preclinical and clinical results of a tran...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Knox, Clayton D., de Kam, Pieter‐Jan, Azer, Karim, Wong, Peggy, Ederveen, Antwan G., Shevell, Diane, Morabito, Christopher, Meehan, Alan G., Liu, Wen, Reynders, Tom, Denef, Jean Francois, Mitselos, Anna, Jonathan, Daniel, Gutstein, David E., Mitra, Kaushik, Sun, Shu Yu, Lo, Michael Man‐Chu, Cully, Doris, Ali, Amjad
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079016/
https://ncbi.nlm.nih.gov/pubmed/27561272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.003493
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