Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains.

In mouse mast cells, both Fc epsilonRI and Fc gammaRIII are alpha beta gamma2 tetrameric complexes in which different alpha chains confer IgE or IgG ligand recognition while the signaling FcR beta and gamma chains are identical. We used primarily noninvasive techniques (changes in body temperature,...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Dombrowicz, D, Flamand, V, Miyajima, I, Ravetch, J V, Galli, S J, Kinet, J P
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 1997
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507899/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9062349/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119256
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