Targeted inhibition of the COP9 signalosome for treatment of cancer

The COP9 signalosome (CSN) is a central component of the activation and remodelling cycle of cullin-RING E3 ubiquitin ligases (CRLs), the largest enzyme family of the ubiquitin–proteasome system in humans. CRLs are implicated in the regulation of numerous cellular processes, including cell cycle pro...

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Pubblicato in:Nat Commun
Autori principali: Schlierf, Anita, Altmann, Eva, Quancard, Jean, Jefferson, Anne B., Assenberg, René, Renatus, Martin, Jones, Matthew, Hassiepen, Ulrich, Schaefer, Michael, Kiffe, Michael, Weiss, Andreas, Wiesmann, Christian, Sedrani, Richard, Eder, Jörg, Martoglio, Bruno
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078989/
https://ncbi.nlm.nih.gov/pubmed/27774986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13166
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