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Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

We have produced transgenic mice whose livers express a dominant positive NH2-terminal fragment of sterol regulatory element binding protein-1c (SREBP-1c). Unlike full-length SREBP-1c, the NH2-terminal fragment enters the nucleus without a requirement for proteolytic release from cell membranes, and...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Shimano, H, Horton, J D, Shimomura, I, Hammer, R E, Brown, M S, Goldstein, J L
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 1997
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507891/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9062341/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119248
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