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Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1.

The ubiquitin-activating enzyme E1 catalyzes the first step in ubiquitin conjugation. We have cloned and sequenced the cDNA for human E1. This clone predicts a protein of 110,450 Da. Cys-194 lies within a region of identity to active-site Cys-88 of the ubiquitin carrier protein E2, suggesting a pote...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Handley, P M, Mueckler, M, Siegel, N R, Ciechanover, A, Schwartz, A L
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50789/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1986373/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.1.258
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