HBV core promoter mutations and AKT upregulate S-phase kinase-associated protein 2 to promote postoperative hepatocellular carcinoma progression

Mutations in the hepatitis B virus (HBV) core promoter (CP) have been shown to be associated with hepatocellular carcinoma (HCC). The CP region overlaps HBV X gene, which activates AKT to regulate hepatocyte survival. However, the cooperation between these two cascades in HCC progression remains poo...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Chen, Lubiao, Gu, Lin, Gu, Yurong, Wang, Hongbo, Deng, Meihai, Stamataki, Zania, Oo, Ye Htun, Huang, Yuehua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078796/
https://ncbi.nlm.nih.gov/pubmed/27779207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35917
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