Hydrotropic Solubilization of Lipophilic Drugs for Oral Delivery: The Effects of Urea and Nicotinamide on Carbamazepine Solubility–Permeability Interplay

Hydrotropy refers to increasing the water solubility of otherwise poorly soluble compound by the presence of small organic molecules. While it can certainly increase the apparent solubility of a lipophilic drug, the effect of hydrotropy on the drugs’ permeation through the intestinal membrane has no...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Beig, Avital, Lindley, David, Miller, Jonathan M., Agbaria, Riad, Dahan, Arik
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078674/
https://ncbi.nlm.nih.gov/pubmed/27826241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00379
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