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Multiple Cranial Organ Defects after Conditionally Knocking Out Fgf10 in the Neural Crest

Fgf10 is necessary for the development of a number of organs that fail to develop or are reduced in size in the null mutant. Here we have knocked out Fgf10 specifically in the neural crest driven by Wnt1cre. The Wnt1creFgf10fl/fl mouse phenocopies many of the null mutant defects, including cleft pal...

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Pubblicato in:Front Physiol
Autori principali: Teshima, Tathyane H. N., Lourenco, Silvia V., Tucker, Abigail S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078472/
https://ncbi.nlm.nih.gov/pubmed/27826253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2016.00488
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