Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells

We investigated whether platelets prime colon cancer cells for metastasis and whether pharmacological inhibition of platelet function may prevent it. Coculturing HT29 human colon carcinoma cells with human platelets led to the induction of mesenchymal-like cancer cells characterized by downregulatio...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Guillem-Llobat, Paloma, Dovizio, Melania, Bruno, Annalisa, Ricciotti, Emanuela, Cufino, Valerio, Sacco, Angela, Grande, Rosalia, Alberti, Sara, Arena, Vincenzo, Cirillo, Mariangela, Patrono, Carlo, FitzGerald, Garret A., Steinhilber, Dieter, Sgambato, Alessandro, Patrignani, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078026/
https://ncbi.nlm.nih.gov/pubmed/27074574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8655
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