A novel agent exerts antitumor activity in breast cancer cells by targeting mitochondrial complex II

The mitochondrial respiratory chain, including mitochondrial complex II, has emerged as a potential target for cancer therapy. In the present study, a novel conjugate of danshensu (DSS) and tetramethylpyrazine (TMP), DT-010, was synthesized. Our results showed that DT-010 is more potent than its par...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Liang, Zhang, Xiaojing, Cui, Guozhen, Chan, Judy Yuet-Wa, Wang, Li, Li, Chuwen, Shan, Luchen, Xu, Changjiang, Zhang, Qingwen, Wang, Yuqiang, Di, Lijun, Lee, Simon Ming-Yuen
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077996/
https://ncbi.nlm.nih.gov/pubmed/27081033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8410
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