Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats.

The long-term administration of N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthesis, produces coronary vascular remodeling and myocardial hypertrophy in animals. This study used a rat model to investigate the role of angiotensin I converting enzyme (ACE) in the pa...

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Main Authors: Takemoto, M, Egashira, K, Usui, M, Numaguchi, K, Tomita, H, Tsutsui, H, Shimokawa, H, Sueishi, K, Takeshita, A
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1997
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC507795/
https://ncbi.nlm.nih.gov/pubmed/9005996
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