DNA aptamers block L-selectin function in vivo. Inhibition of human lymphocyte trafficking in SCID mice.

Selectins participate in the initial events leading to leukocyte extravasation from the blood into tissues. Thus the selectins have generated much interest as targets for antiinflammatory agents. Therapeutic molecules based on the monomeric carbohydrate ligand sialyl Lewis X (SLe(X)) have low affini...

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Autors principals: Hicke, B J, Watson, S R, Koenig, A, Lynott, C K, Bargatze, R F, Chang, Y F, Ringquist, S, Moon-McDermott, L, Jennings, S, Fitzwater, T, Han, H L, Varki, N, Albinana, I, Willis, M C, Varki, A, Parma, D
Format: Artigo
Idioma:Inglês
Publicat: 1996
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC507731/
https://ncbi.nlm.nih.gov/pubmed/8981912
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