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N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells
[Image: see text] N-Myristoyltransferase (NMT) covalently attaches a C14 fatty acid to the N-terminal glycine of proteins and has been proposed as a therapeutic target in cancer. We have recently shown that selective NMT inhibition leads to dose-responsive loss of N-myristoylation on more than 100 p...
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| Wydane w: | ACS Chem Biol |
|---|---|
| Główni autorzy: | , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Chemical
Society
2016
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| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5077176/ https://ncbi.nlm.nih.gov/pubmed/27267252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00371 |
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