Expression and functional assessment of a truncated cardiac troponin T that causes hypertrophic cardiomyopathy. Evidence for a dominant negative action.

Mutations in the beta-myosin heavy chain gene are believed to cause hypertrophic cardiomyopathy (HCM) by acting as dominant negative alleles. In contrast, a truncated cardiac troponin T (TnT) that causes HCM implies that altered stoichiometry of contractile proteins may also cause cardiac hypertroph...

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Pubblicato in:	J Clin Invest
Autori principali:	Watkins, H, Seidman, C E, Seidman, J G, Feng, H S, Sweeney, H L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507702/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8958207/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119063
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