Biochemical Characterization of Bifunctional 3-Deoxy-β-d-manno-oct-2-ulosonic Acid (β-Kdo) Transferase KpsC from Escherichia coli Involved in Capsule Biosynthesis

3-Deoxy-d-manno-oct-2-ulosonic acid (Kdo) is an essential component of bacterial lipopolysaccharides, where it provides the linkage between lipid and carbohydrate moieties. In all known LPS structures, Kdo residues possess α-anomeric configurations, and the corresponding inverting α-Kdo transferases...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Ovchinnikova, Olga G., Doyle, Liam, Huang, Bo-Shun, Kimber, Matthew S., Lowary, Todd L., Whitfield, Chris
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076823/
https://ncbi.nlm.nih.gov/pubmed/27535220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.751115
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