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Impaired glucose homeostasis in insulin-like growth factor binding protein-1 transgenic mice.

Transgenic mice that overexpressed IGFBP-1 are hyperinsulinemic in the first week of life and gradually develop fasting hyperglycemia. In adult transgenic mice, the hypoglycemic response to IGF-I but not insulin or des (1-3) IGF-I was attenuated (P < 0.05) compared with wild-type mice. Furthermor...

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Main Authors: Rajkumar, K, Krsek, M, Dheen, S T, Murphy, L J
格式: Artigo
語言:Inglês
出版: 1996
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC507621/
https://ncbi.nlm.nih.gov/pubmed/8878433
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