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Endogenous interleukin 6 production in multiple myeloma patients treated with chimeric monoclonal anti-IL6 antibodies indicates the existence of a positive feed-back loop.

In vitro as well as in vivo observations have shown that IL6 plays a key role in the pathogenesis of multiple myeloma. Therefore we started a phase I/II dose escalating study with chimeric monoclonal anti-IL6 antibodies (cMab) in multiple myeloma (MM) patients resistant to second-line chemotherapy....

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Detalhes bibliográficos
Main Authors: van Zaanen, H C, Koopmans, R P, Aarden, L A, Rensink, H J, Stouthard, J M, Warnaar, S O, Lokhorst, H M, van Oers, M H
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC507571/
https://ncbi.nlm.nih.gov/pubmed/8823310
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