Malignant mesothelioma effusions are infiltrated by CD3(+) T cells highly expressing PD-L1 and the PD-L1(+) tumor cells within these effusions are susceptible to ADCC by the anti-PD-L1 antibody avelumab

INTRODUCTION: The functional aspects of programmed death 1 (PD-1) and PD ligand 1 (PD-L1) immune checkpoints in malignant mesothelioma have not been studied. METHODS: Tumor samples from 65 patients with mesothelioma were evaluated for PD-L1 expression by immunohistochemistry and its prognostic signi...

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Udgivet i:J Thorac Oncol
Main Authors: Khanna, Swati, Thomas, Anish, Abate-Daga, Daniel, Zhang, Jingli, Morrow, Betsy, Steinberg, Seth M., Orlandi, Augusto, Ferroni, Patrizia, Schlom, Jeffrey, Guadagni, Fiorella, Hassan, Raffit
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075512/
https://ncbi.nlm.nih.gov/pubmed/27544053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2016.07.033
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