Linomide prevents the lethal effect of anti-Fas antibody and reduces Fas-mediated ceramide production in mouse hepatocytes.

Fas is an apoptosis-signaling receptor molecule expressed in vivo on thymocytes, liver, heart, and ovary. In vivo administration of the anti-Fas Jo2 antibody in mice induces severe apoptotic liver damage leading to fulminant hepatitis and death. Linomide, a quinoline 3-carboxamide, inhibits apoptosi...

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Bibliografski detalji
Glavni autori: Redondo, C, Flores, I, Gonzalez, A, Nagata, S, Carrera, A C, Merida, I, Martinez-A, C
Format: Artigo
Jezik:Inglês
Izdano: 1996
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC507547/
https://ncbi.nlm.nih.gov/pubmed/8787688
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