Lonidamine induces apoptosis in drug-resistant cells independently of the p53 gene.

Lonidamine, a dichlorinated derivative of indazole-3-carboxylic acid, was shown to play a significant role in reversing or overcoming multidrug resistance. Here, we show that exposure to 50 microg/ml of lonidamine induces apoptosis in adriamycin and nitrosourea-resistant cells (MCF-7 ADR(r) human br...

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Bibliografiske detaljer
Main Authors: Del Bufalo, D, Biroccio, A, Soddu, S, Laudonio, N, D'Angelo, C, Sacchi, A, Zupi, G
Format: Artigo
Sprog:Inglês
Udgivet: 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC507539/
https://ncbi.nlm.nih.gov/pubmed/8787680
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