The receptor for advanced glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway. Implications for the pathogenesis of dialysis-related amyloidosis.

An important component of amyloid fibrils in dialysis-related amyloidosis is a form of beta2microglobulin modified with advanced glycation end products (AGEs) of the Maillard reaction, known as AGE-beta2M. We demonstrate here that the interaction of AGE-beta2M with mononuclear phagocytes (MPs), cell...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Miyata, T, Hori, O, Zhang, J, Yan, S D, Ferran, L, Iida, Y, Schmidt, A M
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507528/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8787669/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118889
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