Antileishmanial Activity of Ezetimibe: Inhibition of Sterol Biosynthesis, In Vitro Synergy with Azoles, and Efficacy in Experimental Cutaneous Leishmaniasis

Leishmaniasis affects mainly low-income populations in tropical regions. Radical innovation in drug discovery is time-consuming and expensive, imposing severe restrictions on the ability to launch new chemical entities for the treatment of neglected diseases. Drug repositioning is an attractive stra...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Andrade-Neto, Valter Viana, Cunha-Júnior, Edézio Ferreira, do Canto-Cavalheiro, Marilene Marcuzzo, Atella, Geórgia Correa, Fernandes, Talita de Almeida, Costa, Paulo Roberto Ribeiro, Torres-Santos, Eduardo Caio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075094/
https://ncbi.nlm.nih.gov/pubmed/27600041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01545-16
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