Dual Targeting of Cell Wall Precursors by Teixobactin Leads to Cell Lysis

Teixobactin represents the first member of a newly discovered class of antibiotics that act through inhibition of cell wall synthesis. Teixobactin binds multiple bactoprenol-coupled cell wall precursors, inhibiting both peptidoglycan and teichoic acid synthesis. Here, we show that the impressive bac...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Homma, Tomoyuki, Nuxoll, Austin, Gandt, Autumn Brown, Ebner, Patrick, Engels, Ina, Schneider, Tanja, Götz, Friedrich, Lewis, Kim, Conlon, Brian P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075054/
https://ncbi.nlm.nih.gov/pubmed/27550357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01050-16
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