Origin of a folded repeat protein from an intrinsically disordered ancestor

Repetitive proteins are thought to have arisen through the amplification of subdomain-sized peptides. Many of these originated in a non-repetitive context as cofactors of RNA-based replication and catalysis, and required the RNA to assume their active conformation. In search of the origins of one of...

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Pubblicato in:eLife
Autori principali: Zhu, Hongbo, Sepulveda, Edgardo, Hartmann, Marcus D, Kogenaru, Manjunatha, Ursinus, Astrid, Sulz, Eva, Albrecht, Reinhard, Coles, Murray, Martin, Jörg, Lupas, Andrei N
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2016
Soggetti:
Computational and Systems Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074805/
https://ncbi.nlm.nih.gov/pubmed/27623012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16761
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