Desipramine Increases Genioglossus Activity and Reduces Upper Airway Collapsibility during Non-REM Sleep in Healthy Subjects

Rationale: Obstructive sleep apnea is a state-dependent disease. One of the key factors that triggers upper airway collapse is decreased pharyngeal dilator muscle activity during sleep. To date, there have not been effective methods to reverse pharyngeal hypotonia pharmacologically in sleeping human...

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Publicado en:Am J Respir Crit Care Med
Autores principales: Taranto-Montemurro, Luigi, Edwards, Bradley A., Sands, Scott A., Marques, Melania, Eckert, Danny J., White, David P., Wellman, Andrew
Formato: Artigo
Lenguaje:Inglês
Publicado: American Thoracic Society 2016
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074653/
https://ncbi.nlm.nih.gov/pubmed/26967681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201511-2172OC
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