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Desipramine Increases Genioglossus Activity and Reduces Upper Airway Collapsibility during Non-REM Sleep in Healthy Subjects

Rationale: Obstructive sleep apnea is a state-dependent disease. One of the key factors that triggers upper airway collapse is decreased pharyngeal dilator muscle activity during sleep. To date, there have not been effective methods to reverse pharyngeal hypotonia pharmacologically in sleeping human...

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Bibliografiske detaljer
Udgivet i:Am J Respir Crit Care Med
Main Authors: Taranto-Montemurro, Luigi, Edwards, Bradley A., Sands, Scott A., Marques, Melania, Eckert, Danny J., White, David P., Wellman, Andrew
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074653/
https://ncbi.nlm.nih.gov/pubmed/26967681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201511-2172OC
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