IBMPFD Disease-Causing Mutant VCP/p97 Proteins Are Targets of Autophagic-Lysosomal Degradation

The ubiquitin-proteasome system (UPS) degrades soluble proteins and small aggregates, whereas macroautophagy (autophagy herein) eliminates larger protein aggregates, tangles and even whole organelles in a lysosome-dependent manner. VCP/p97 was implicated in both pathways. VCP/p97 mutations cause a r...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Bayraktar, Oznur, Oral, Ozlem, Kocaturk, Nur Mehpare, Akkoc, Yunus, Eberhart, Karin, Kosar, Ali, Gozuacik, Devrim
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074563/
https://ncbi.nlm.nih.gov/pubmed/27768726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164864
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