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Ablation of the decorin gene enhances experimental hepatic fibrosis and impairs hepatic healing in mice
Accumulation of connective tissue is a typical feature of chronic liver diseases. Decorin, a small leucine-rich proteoglycan, regulates collagen fibrillogenesis during development, and by directly blocking the bioactivity of transforming growth factor-β1 (TGFβ1), it exerts a protective effect agains...
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| Publicado no: | Lab Invest |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5074558/ https://ncbi.nlm.nih.gov/pubmed/20956977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2010.172 |
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