A Human Phospholamban Promoter Polymorphism in Dilated Cardiomyopathy Alters Transcriptional Regulation by Glucocorticoids

Depressed calcium handling by the sarcoplasmic reticulum (SR) Ca-ATPase and its regulator phospholamban (PLN) is a key characteristic of human and experimental heart failure. Accumulating evidence indicates that increases in the relative levels of PLN to Ca-ATPase in failing hearts and resulting inh...

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Bibliographic Details
Published in:Hum Mutat
Main Authors: Haghighi, Kobra, Chen, Guoli, Sato, Yoji, Fan, Guo-Chang, He, Suiwen, Kolokathis, Fotis, Pater, Luke, Paraskevaidis, Ioannis, Jones, W. Keith., Dorn, Gerald W., Kremastinos, Dimitrios Th., Kranias, Evangelia G.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074532/
https://ncbi.nlm.nih.gov/pubmed/18241046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.20692
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