Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine.

The phenomenon of alkylation tolerance has been observed in cells that are deficient in some component of the DNA mismatch repair (MMR) system. An alkylation-induced cell cycle arrest had been reported previously in one MMR-proficient cell line, whereas a MMR-defective clone derived from this line e...

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Publicado en:	J Clin Invest
Autores principales:	Carethers, J M, Hawn, M T, Chauhan, D P, Luce, M C, Marra, G, Koi, M, Boland, C R
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical Investigation 1996
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507417/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8690794/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118767
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