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Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.

We asked whether the well known starvation-induced impairment of glucose-stimulated insulin secretion (GSIS) seen in isolated rat pancreas preparations also applies in vivo. Accordingly, fed and 18-24-h-fasted rats were subjected to an intravenous glucose challenge followed by a hyperglycemic clamp...

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Publicado no:J Clin Invest
Principais autores: Stein, D T, Esser, V, Stevenson, B E, Lane, K E, Whiteside, J H, Daniels, M B, Chen, S, McGarry, J D
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507365/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8675683/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118727
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