Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2

BACKGROUND: Accumulating researches have shown that epithelial-mesenchymal transition (EMT) contributes to tumor metastasis. Leptin, a key adipokine secreted from adipocytes, shapes the tumor microenvironment, potentiates the migration of breast cancer cells and angiogenesis, and is also involved in...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Wei, Lan, Li, Kuangfa, Pang, Xueli, Guo, Bianqin, Su, Min, Huang, Yunxiu, Wang, Nian, Ji, Feihu, Zhong, Changli, Yang, Junhong, Zhang, Zhiqian, Jiang, Yulin, Liu, Yifeng, Chen, Tingmei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5073421/
https://ncbi.nlm.nih.gov/pubmed/27769315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0446-4
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