Dual PI3K/ERK inhibition induces necroptotic cell death of Hodgkin Lymphoma cells through IER3 downregulation

PI3K/AKT and RAF/MEK/ERK pathways are constitutively activated in Hodgkin lymphoma (HL) patients, thus representing attractive therapeutic targets. Here we report that the PI3K/ERK dual inhibitor AEZS-136 induced significant cell proliferation inhibition in L-540, SUP-HD1, KM-H2 and L-428 HL cell li...

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Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Locatelli, Silvia Laura, Careddu, Giuseppa, Stirparo, Giuliano Giuseppe, Castagna, Luca, Santoro, Armando, Carlo-Stella, Carmelo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5073341/
https://ncbi.nlm.nih.gov/pubmed/27767172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35745
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