Optical manipulation of the alpha subunits of heterotrimeric G proteins using photoswitchable dimerization systems

Alpha subunits of heterotrimeric G proteins (Gα) are involved in a variety of cellular functions. Here we report an optogenetic strategy to spatially and temporally manipulate Gα in living cells. More specifically, we applied the blue light-induced dimerization system, known as the Magnet system, an...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Yu, Gaigai, Onodera, Hiroyuki, Aono, Yuki, Kawano, Fuun, Ueda, Yoshibumi, Furuya, Akihiro, Suzuki, Hideyuki, Sato, Moritoshi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5073340/
https://ncbi.nlm.nih.gov/pubmed/27767077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35777
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