Intravenous somatic gene transfer with antisense tissue factor restores blood flow by reducing tumor necrosis factor-induced tissue factor expression and fibrin deposition in mouse meth-A sarcoma.

Fibrin is deposited on the endothelial cell surface in the vasculature of murine methylcholanthrene A-induced sarcomas after injection of tumor necrosis factor (TNF). Capillary endothelial cells of the tumor vascular bed become positive for tissue factor after TNF injection, based on immunocytochemi...

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Detalhes bibliográficos
Main Authors: Zhang, Y., Deng, Y., Wendt, T., Liliensiek, B., Bierhaus, A., Greten, J., He, W., Chen, B., Hach-Wunderle, V., Waldherr, R., Ziegler, R., Männel, D., Stern, D. M., Nawroth, P. P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC507300/
https://ncbi.nlm.nih.gov/pubmed/8636400
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