A Candidate Trans-acting Modulator of Fetal Hemoglobin Gene Expression in the Arab-Indian Haplotype of Sickle Cell Anemia: —ANTXR1 Variants and HbF—

Fetal hemoglobin (HbF) levels are higher in the Arab-Indian (AI) β-globin gene haplotype of sickle cell anemia compared with African-origin haplotypes. To study genetic elements that effect HbF expression in the AI haplotype we completed whole genome sequencing in 14 Saudi AI haplotype sickle hemogl...

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Pubblicato in:Am J Hematol
Autori principali: Vathipadiekal, Vinod, Farrell, John J., Wang, Shuai, Edward, Heather L., Shappell, Heather, Al-Rubaish, A.M., Al-Muhanna, Fahad, Naserullah, Z., Alsuliman, A., Qutub, Hatem Othman, Simkin, Irene, Farrer, Lindsay A., Jiang, Zhihua, Luo, Hong-Yuan, Huang, Shengwen, Mostoslavsky, Gustavo, Murphy, George J., Patra, Pradeep.K., Chui, David H.K., Alsultan, Abdulrahman, Al-Ali, Amein K., Sebastiani, Paola., Steinberg, Martin. H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072989/
https://ncbi.nlm.nih.gov/pubmed/27501013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.24527
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