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Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production.
We investigated the role of the costimulatory molecules, CD40 and its ligand CD40L, in the pathogenesis of human SLE. In comparison to normal subjects or patients in remission, PBMC from active lupus patients had a 21-fold increase in the frequency of CD40L-expressing, CD4+T cells. However, the expr...
Kaydedildi:
| Yayımlandı: | J Clin Invest |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Clinical Investigation
1996
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507281/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8621796/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118643 |
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