Substance P Promotes the Proliferation, but Inhibits Differentiation and Mineralization of Osteoblasts from Rats with Spinal Cord Injury via RANKL/OPG System

Spinal cord injury (SCI) causes a significant amount of bone loss, which results in osteoporosis (OP). The neuropeptide substance P (SP) and SP receptors may play important roles in the pathogenesis of OP after SCI. To identify the roles of SP in the bone marrow mesenchymal stem cell derived osteobl...

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Bibliographic Details
Published in:PLoS One
Main Authors: Liu, Hai-Juan, Yan, Hua, Yan, Jun, Li, Hao, Chen, Liang, Han, Li-Ren, Yang, Xiao-Fei
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072631/
https://ncbi.nlm.nih.gov/pubmed/27764190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165063
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