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Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans. A murine transgenic model.

Urokinase (uPA) is hypothesized to provide proteolytic activity enabling inflammatory cells to traverse tissues during recruitment, and it is implicated as a cytokine modulator. Definitive evaluation of these hypotheses in vivo has previously been impossible because uPA could not completely and irre...

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Published in:J Clin Invest
Main Authors: Gyetko, M R, Chen, G H, McDonald, R A, Goodman, R, Huffnagle, G B, Wilkinson, C C, Fuller, J A, Toews, G B
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1996
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507249/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8621764/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118611
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