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The Neurotoxic Tau(45-230) Fragment Accumulates in Upper and Lower Motor Neurons in Amyotrophic Lateral Sclerosis Subjects

Amyotrophic lateral sclerosis (ALS) is a progressive and lethal neurodegenerative disease characterized by loss of upper and lower motor neurons leading to muscle paralysis in affected individuals. Numerous mechanisms have been implicated in the death of these neurons. However, the pathobiology of t...

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Publicat a:Mol Med
Autors principals: Vintilescu, Claudia R, Afreen, Sana, Rubino, Ashlee E, Ferreira, Adriana
Format: Artigo
Idioma:Inglês
Publicat: Feinstein Institute for Medical Research 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072411/
https://ncbi.nlm.nih.gov/pubmed/27496042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2016.00095
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