Vagotomy Affects the Development of Oral Tolerance and Increases Susceptibility to Develop Colitis Independently of α-7 Nicotinic Receptor

Vagotomy (VGX) increases the susceptibility to develop colitis suggesting a crucial role for the cholinergic anti-inflammatory pathway in the regulation of the immune responses. Since oral tolerance and the generation of regulatory T cells (Tregs) are crucial to preserve mucosal immune homeostasis,...

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Publicat a:Mol Med
Autors principals: Di Giovangiulio, Martina, Bosmans, Goele, Meroni, Elisa, Stakenborg, Nathalie, Florens, Morgane, Farro, Giovanna, Gomez-Pinilla, Pedro J, Matteoli, Gianluca, Boeckxstaens, Guy E
Format: Artigo
Idioma:Inglês
Publicat: Feinstein Institute for Medical Research 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072409/
https://ncbi.nlm.nih.gov/pubmed/27341335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2016.00062
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