Intramolecular inhibition of human defensin HNP-1 by its propiece.

We examined mechanisms that protect host defense cells from their cytotoxic effector molecules. Human neutrophil peptides (HNP) 1-3 are microbicidal and cytotoxic defensins, initially synthesized as 94-amino acid preproHNP(1-94), cotranslationally proteolyzed to proHNP(20-94), then converted by remo...

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Pubblicato in:	J Clin Invest
Autori principali:	Valore, E V, Martin, E, Harwig, S S, Ganz, T
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507226/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8601627/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118588
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