Macrophage/microglial-mediated primary demyelination and motor disease induced by the central nervous system production of interleukin-3 in transgenic mice.

Activated macrophage/microglia may mediate tissue injury in a variety of CNS disorders. To examine this, transgenic mice were developed in which the expression of a macrophage/microglia activation cytokine, interleukin-3 (IL-3), was targeted to astrocytes using a murine glial fibrillary acidic prote...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Chiang, C S, Powell, H C, Gold, L H, Samimi, A, Campbell, I L
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507212/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8617885/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118574
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