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Suppression of cell-mediated and humoral immune responses by an interleukin-2-immunoglobulin fusion protein in mice.

Interleukin-2 (IL-2) plays a pivotal role in the cellular and humoral immune responses directed against foreign antigens. We characterized the in vitro and in vivo properties of a chimeric protein consisting of mouse IL-2 fused to the mouse IgG2b Fc domains. This fusion protein binds to IL-2 and Fc...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Kunzendorf, U, Pohl, T, Bulfone-Paus, S, Krause, H, Notter, M, Onu, A, Walz, G, Diamantstein, T
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1996
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507172/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8636431/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118534
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