Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology

Human neural progenitors derived from pluripotent stem cells develop into electrophysiologically active neurons at heterogeneous rates, which can confound disease-relevant discoveries in neurology and psychiatry. By combining patch clamping, morphological and transcriptome analysis on single human n...

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Publicado no:Mol Psychiatry
Main Authors: Bardy, Cedric, van den Hurk, Mark, Kakaradov, Boyko, Erwin, Jennifer, Jaeger, Baptiste, Hernandez, Ruben V, Eames, Tameji, Paucar, Andres, Gorris, Mark, Marchand, Cynthia, Jappelli, Roberto, Barron, Jerika, Bryant, Alex, Kellogg, Mariko, Lasken, Roger, Rutten, Bart P.F., Steinbusch, Harry W.M., Yeo, Gene W., Gage, Fred H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5071135/
https://ncbi.nlm.nih.gov/pubmed/27698428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2016.158
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