Red cell membrane remodeling in sickle cell anemia. Sequestration of membrane lipids and proteins in Heinz bodies.

In red cells from patients with sickle cell anemia, hemoglobin S denatures and forms Heinz bodies. Binding of Heinz bodies to the inner surface of the sickle cell membrane promotes clustering and colocalization of the membrane protein band 3, outer surface-bound autologous IgG and, to some extent, t...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Liu, S C, Yi, S J, Mehta, J R, Nichols, P E, Ballas, S K, Yacono, P W, Golan, D E, Palek, J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507059/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8550846/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118402
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Red cell membrane remodeling in sickle cell anemia. Sequestration of membrane lipids and proteins in Heinz bodies.

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