Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma

PURPOSE: Symptomatic epilepsy is a common complication of glioblastoma and requires pharmacotherapy. Several uncontrolled retrospective case series and a post hoc analysis of the registration trial for temozolomide indicated an association between valproic acid (VPA) use and improved survival outcom...

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Bibliographic Details
Published in:J Clin Oncol
Main Authors: Happold, Caroline, Gorlia, Thierry, Chinot, Olivier, Gilbert, Mark R., Nabors, L. Burt, Wick, Wolfgang, Pugh, Stephanie L., Hegi, Monika, Cloughesy, Timothy, Roth, Patrick, Reardon, David A., Perry, James R., Mehta, Minesh P., Stupp, Roger, Weller, Michael
Format: Artigo
Language:Inglês
Published: American Society of Clinical Oncology 2016
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Original Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5070573/
https://ncbi.nlm.nih.gov/pubmed/26786929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2015.63.6563
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